A new study published on Thursday reveals that the effectiveness of the Pfizer-BioNTech vaccine against coronavirus declines faster than of the AstraZeneca vaccine.

Researchers at Oxford University stated that “Two doses of Pfizer-BioNTech have greater initial effectiveness against new COVID-19 infections, but this declines faster compared with two doses of Oxford-AstraZeneca”.


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The study has not been peer-reviewed; it is based on the results of the survey of PCR tests conducted by Britain’s Office for National Statistics in randomly selected households between December 2020 and August 2021.

The Nuffield Department of Medicine at the university highlighted that “the dynamics of immunity following second doses differed significantly” between the two vaccines.

Pfizer had “greater initial effectiveness” but it rapidly “declines in protection against high viral burden and symptomatic infection”.


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The scientists disclosed that the “results suggest that after four to five months, the effectiveness of these two vaccines would be similar,” and added that the long-term effects must be studied.

The United States has announced its plan to offer booster vaccines to Americans in September to increase antibody levels following concerns of the decline in the effectiveness of the Pfizer and Moderna vaccines.

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